The versatility of our UAN nanoparticles in both payload encapsulation and presentation of targeting ligands may facilitate developing a robust platform for evaluating various combinations of cancer drugs and molecular interactions toward developing effective cancer therapy formulations.
Mechanically induced trapping of molecular interactions (MITOMI) was developed which is capable of detecting low affinity TF-DNA binding using a microfluidic device [ 7].
Results consistently echo whole cell-cell behavior [20], [21], [22], supporting the validity of this approach for both dissecting the link between surface molecular interactions and T-cell triggering, and developing efficient artificial T-cell activation strategies.
The second part of the talk will describe chemogenetic tools we have developed for mapping molecular interactions in living cells (e.g., APEX and TurboID).
A dynamic model of the TOL (pWW0) plasmid of Pseudomonas putida mt-2 has been developed, describing the molecular interactions that lead to the transcription of the upper and meta operons, known to produce the enzymes for the oxidative catabolism of m-xylene.
DASMI has been developed to support molecular interactions at different levels (Fig. 1).
In addition, computational methods have been developed for predicting molecular interactions, some of which reach prediction quality comparable to that of experimental high-throughput data (Ramírez et al., 2007; Shoemaker and Panchenko, 2007).
To account for the intrinsic noise in genetic and molecular interactions, probabilistic Boolean networks (PBNs) have been developed as a generalization of BNs [ 14- 16].
It also provides an insight, through a biophysical model, of the mechanistic causes of how DMIs develop for coevolved pairwise molecular interactions.
In the Synthetic Neurobiology Group, Choueiri's research involves developing neurotechnologies to map the molecular interactions of the brain, to reveal the fundamental mechanisms of brain function and repair dysfunction.
In the field of molecular interactions, several extensively used plugins for PyMOL were developed.
