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Since FunWalk considers functional terms of annotations, rather than genes, it only considers terms that have common annotations across molecular interactions defined in the network.
Combining temporal expression patterns with direct and indirect molecular interactions defined by pathway analysis, we hypothesize that NF-κB-regulated inflammation is down-regulated early and moderates as blood ethanol levels decrease.
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HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumoricidal activity that also triggers tumor cell detachment in vitro and in vivo, suggesting that molecular interactions defining detachment are perturbed in cancer cells.
For this purpose, we have constructed a novel dynamic mathematical model of key molecular interactions defining these networks.
Therefore, these molecular interactions define a complex and rigid structure forming a material that is recalcitrant to hydrolysis [ 4].
Such molecular interactions that define the host-microbe interface are generally non-covalent in nature and frequently involve extensive intermolecular interfaces and multivalent binding.
Recent technological advances have enabled the probing of how primary wall structures and molecular interactions of polysaccharides define their biomechanical (and hence functional) properties.
We specify the molecular interactions between components by defining a Qualitative network of the studied system.
These recent reports defined molecular interactions that might play a role in the direct activation of B cells by HIV.
In order to refine the pharmacophore analysis and evaluate the outcomes of the CoMFA and CoMSIA study we used pseudoreceptor modeling software PrGen to generate a putative binding site surrogate that is composed of eight amino acid residues corresponding to the defined molecular interactions.
The weighted molecular interaction network was defined as a combination of mouse protein-protein and protein-DNA interactions from multiple sources including HitPredict [ 9], InnateDB [ 10], TRANSFAC [ 11] and KEGG [ 12].
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