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Our reconstruction of the molecular interactions affected by glaucoma revealed multi-domain biological networks controlling activation of ONHAs at the level of intercellular stimuli, intracellular signaling and core effectors.
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Thus, we provide the first description of subunit-specific molecular interactions that affect RT heterodimer function and virus infection in vivo.
After having established the types of data we wanted to capture, we defined new CV terms that can be used as interaction attribute names in the PSI-MI format to link molecular interactions that affect each other and annotate different aspects of their cooperative behaviour (Tables 1 and 2, Figure 4).
The ability to find genetic interactions affecting molecular phenotypes also suggests a hypothesis driven path by which genetic interactions underlying more complex traits may be identified.
It would be interesting to learn how such inter-molecular and inter-pathway interactions affect β-cell expansion.
To understand the prevalence and importance of these interactions, work has focused on higher-order genome organization, identifying which DNA sequence elements physically interact, and determining how these interactions affect transcription at the molecular level.
This structural change in BC, that involves a variation in inter- and intramolecular interactions (hydrogen-bonding interactions), affects steeply their molecular dynamics.
42, 43 Although the N-loop is not involved in direct molecular interactions, it nevertheless affects the IAPP aggregation kinetics indirectly, since N-loop removal was found to change the mass/length distribution and kinetics of the h-IAPP fiber.
Interfacial interactions affecting polyimide reliability.
Not all epistatic interactions affect GR, however.
A pathological osteoblastic nature of bone metastases from prostate cancer is derived by the complex molecular interactions behind prostate cancer, affecting the balanced activity of osteoclasts and osteoblasts (Florimonte et al., 2016).
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