Sentence examples for molecular interaction path from inspiring English sources
The reason why we formulated this as a hypothesis rather than a theorem is that we assumed that the significant (molecular) interaction path follows the shortest path connecting two genes.
Here we assume that the significant (molecular) interaction path follows the shortest paths connecting two genes.
Then, the EMPath method was used to detect enriched up- and down-regulated molecular interaction paths within the network.
We proved the use of our framework by applying it to reveal the molecular interaction paths involved in viral infection.
Previously, a graph-theoretical method called Enriched Molecular Path detection (EMPath) was developed in order to identify molecular interaction paths from multi-level interactome data [ 13].
Thus, transcription and flux data were integratively utilized to find enriched molecular interaction paths associated with the aforementioned differences in the previously observed oxygen-dependent phenotypes [ 21- 23].
The detected molecular interaction paths combined protein-protein interactions and metabolic interactions dependent on the phenotypes compared and the relative weighting used to combine the transcription and flux data.
Scoring the nodes of the interaction network solely with flux data resulted in molecular interaction paths dominated by components of sphingolipid metabolism and protein-protein interactions between them (Additional file 2: Figure S1; FunCat enrichments in Additional file 1).
The detected molecular interaction paths included FAS1 and FAS2 that are involved in the elongation of saturated fatty acids, and FAA1 and FAA4 encoding enzymes catalyzing the import and activation of unsaturated fatty acids available in the growth medium.
In the detected molecular interaction paths PEX14 was further linked to regulators of protein folding (HSP42, SIS1, SSA3) in particular in response to stress, which share a YAP1p binding site [YEASTRACT database July 16, 2013; [ 39- 41]].
In this study, the EMPath method for the detection of molecular interaction paths [ 13] was extended to allow for simultaneous utilization of transcriptome and fluxome data in an integrative manner.
