Understanding design principles of molecular interaction networks is an important goal of molecular systems biology.
Another common computational method uses global centrality measures such as closeness/betweenness on molecular interaction networks to identify the targets.
www.reactome.org KEGG Pathways Large collection of manually drawn pathway maps of molecular interaction networks for various biological processes.
This seed of genes is improved by expanding and re-ranking them in the functional context by reprioritizing them in disease-related molecular interaction networks.
Molecular interaction networks were visualized using Cytoscape [19].
It is mainly used as a bioinformatic software platform for visualizing molecular interaction networks.
The Kyoto Encyclopedia of Genes and Genomes (KEGG) represent the current knowledge on molecular interaction networks such as pathways [17].
This community structure or network modularity has been identified in diverse network systems, including social [18], [19], scientific collaboration [20], metabolic [21], and molecular interaction networks [22] [24].
In this respect, our suggested molecular interaction networks qualify as potential candidates to translate the observed population heterogeneity onto a molecular basis.
The list of RefSeq identifiers was then uploaded to the Ingenuity Pathway Analysis program (Redwood City, CA), enabling exploration of ontology and molecular interaction networks.
We then compiled the layout of the network in Cytoscape, an open source software platform for visualizing molecular interaction networks [44].
