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Using a notation specifically designed for circuit diagram-like representations of bioregulatory networks, we have prepared an updated molecular interaction map of the immediate connections of p53 and Mdm2, which are described as logic elements of the network.
The molecular interaction map was imported into Cytoscape v2.6.3 for decomposition and topological analysis.
The molecular interaction map improves our ability to understand the molecular mechanism involved in RA on the whole.
In particular the MIM (molecular interaction map) notation [ 3] a form of entity-relationship representation and the process description notation (PDN) [ 1], respectively.
In the work presented here, we set out to build a comprehensive and well-annotated molecular interaction map to aid future studies involving gastrin or CCK.
This validation capability is built using Schematron language which has been previously used for Molecular Interaction Map diagram validation (Luna et al., 2011).
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We also used molecular interaction maps to propose a p53 Off On switch in response to DNA damage.
Parodi had managed to convince her of the future importance of molecular interaction maps based on the work of his close friend Kurt Kohn at the National Cancer Institute in the United States.
Molecular interaction maps are a popular graph-based formalism created by Kohn in 1999 (Kohn 1999, Kohn et al. 2006, Luna et al. 2011) that influenced the SBGN standard (Le Novère et al. 2009).
This supports previously published hypotheses that there is a relationship between biologically and topologically significant areas of molecular interaction maps.
The symbol conventions, defined for these molecular interaction maps, accommodate multiprotein assemblies and protein modifications and thus can generate combinatorially large numbers of molecular species.
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molecular perturbation map
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molecular signature map
molecular interaction network
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molecular function map
molecular interaction parameter
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molecular interaction model
molecular interaction pathway
molecular linkage map
molecular interaction experiment
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