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See images of the VisEn molecular imaging system being used on mice.
To help cancer patients and their surgeons beat the odds, medical device company Lightpoint Medical Ltd. has teamed up with product development firm Sagentia to develop the LightPath™ Imaging System, the world's first intra-operative molecular imaging system.
A molecular imaging system shows the telltale signs of tumors.
Made by VisEn Medical of Woburn, the molecular imaging system is allowing researchers to see deeper into the body and look at a wider range of chemical activity than is possible with existing imaging techniques.
The VisEn molecular imaging system relies on large fluorescent-protein probes that interact with disease-related proteins in the body and allow researchers to see where they are and in what concentrations.
Probing disease: A molecular imaging system made by VisEn Medical illuminates the activity of proteins deep inside mice and constructs 3-D images of tumors and other diseased tissue.
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Other molecular imaging systems that use fluorescent probes can't provide 3-D images and can't penetrate deep into the animal.
We constructed fluorescence molecular imaging systems that have two modes: a planner mode (projection imaging) and a multimodality mode (fluorescence molecular tomography and micro-CT).
Unfortunately, the development of molecular imaging systems for breast cancer has lagged behind that for other oncologic processes.
In addition, we were able to utilize a molecular light imaging system to macroscopically image the cells on these materials both with fluorescence and luminescence, as well as quantify the signal from the samples.
Therefore, in this study, an scFv from clone J42 that exhibited a slow dissociation rate (koff ∼10 4 s–1) and a high binding affinity was chosen for fusion with an affibody to generate a heterobivalent receptor molecule to test the efficacy of the scFv-hapten molecular imaging reporter system.
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