Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies are also of interest and will be considered for publication.
Indeed, MRS has good test-retest reliability and, compared with other in vivo imaging biomarkers, such as positron emission tomography (PET) and single photon emission tomography (SPECT), is noninvasive and cheap, and it does not require contrast agents for the molecular imaging involving exposure to radioactive substances.
Molecular imaging generally involves the administration of a labeled molecule in the body, the measurement of the tracer with an imaging device, and the analysis and interpretation of the measured images to give biologically meaningful information.
Given the improved optical properties of these mutants, one or more of them could be a more desirable candidate for molecular imaging studies involving cellular stresses.
PET allows the investigation of both the measurements of cerebral glucose metabolism by F-2-fluoro-2-deoxy-D-glucose (FDG) and the A β amyloid deposition through specific molecular imaging techniques involving radiopharmaceuticals binding to amyloid.
Positron emission topography (PET) allows the investigation of both the measurement of cerebral glucose metabolism by F-2-fluoro-2-deoxy-D-glucose (FDG) and the quantification of A β amyloid deposition through specific molecular imaging techniques involving radiopharmaceuticals binding to amyloid.
A very important aspect of functional/molecular imaging involves the methodology of the acquisition that requires an adequate knowledge of the tracers characteristics, the pathology, the anatomy, the imaging methodologies, and the possible limitations.
There are five imaging modalities available for molecular imaging, including X-ray computed tomography imaging (CT), optical imaging (OI), radionuclide imaging (involving PET and SPECT), ultrasound (US) imaging and magnetic resonance imaging (MRI) [ 9].
Molecular imaging of living organisms involves the visualization of biological processes and cellular functions at the molecular and cellular levels [33].
