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These 198Au-incorporated nanostructures have a great potential for in vivo molecular imaging compared to the disadvantages of radioactive nanomaterials made with chelating agents.
Although I do not doubt the potential of molecular imaging compared with existing anatomic imaging techniques, molecular imaging techniques will likely face the same substantial hurdles to reimbursement".
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For the biological evaluation, 44Sc-labeled derivatives were considered in order to demonstrate that the use of trivalent radiometals is favorable in extending the time period of molecular PET imaging compared to 18F-labeled analogues without changing the pharmacokinetics.
We used noninvasive molecular imaging to compare the distribution and myocardial retention of cells implanted by using clinical delivery routes.
Because percutaneous renal biopsies are regularly performed, new molecular imaging probes can be compared to the biopsies in order to test the correlation of the molecular imaging method with the "gold standard" of disease staging.
In the present study, we quantitatively and qualitatively compared both molecular imaging agents used in PET imaging (18F-FDG vs. 18F-Z HER2-Affibody) and structural imaging modalities (CT vs. MRI).
Two types of affibody-based probes, Cu-DOTA-ZEGFR:1907 for PET, and Alexa680-ZEGFR:1907 for near-infrared fluorescent (NIRF) imaging, were evaluated and compared for molecular imaging of three type of HCC xenograft models.
GNRs are also on a more advantageous size scale for in vivo molecular imaging (tens of nanometers in size) compared to nanoshells (hundreds of nanometers in size).
Compared with other molecular imaging modalities, ultrasound molecular imaging has many advantages including good temporal resolution, quantitative data, real-time practice, noninvasiveness, relatively inexpensive cost, and no ionizing radiation.
However, compared to other molecular imaging modalities, MRI has relatively poor sensitivity, and therefore contrast agents (CAs) are often used to enhance imaging contrast between pathological and normal tissues.
The main advantage of this optical method compared to others in molecular imaging is that it remains non invasive and non-ionizing.
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