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In 2006, another method for c-MET-targeted molecular imaging based on genetic engineering was developed [72].
Thus, molecular imaging based on small molecule probes with intracellular binding site can provide more roundly information about the c-MET activation status.
Remarkably, Jagoda and colleagues not only conducted leading work in the development of antibody-based c-MET-targeted molecular imaging but they also performed extensive research on molecular imaging based on cMBP [67, 68].
Molecular imaging based on positron emission tomography (PET) scanners improves the diagnostic accuracy of conventional imaging techniques.
The statistically significant database of receptor targets on breast cancers that will be created by these studies will enable probe development to allow molecular imaging based on tumor-selective markers.
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Today, molecular imaging methods based on metabolic markers such as 18F-FDG (fluorodeoxyglucose) and 18F/11C-Choline 18F/11C-Cholineed; however, there are known limitations for these tracommonly
Herein, an easy method was developed to fabricate a new type of magnetic resonance imaging/fluorescent integrative molecular imaging probe based on Gd@C82.
But even a molecular imaging approach based on a single probe may be insufficient, as alternative dysregulated signal pathways may replace the function of the targeted pathway [93, 94].
However, molecular imaging approaches based on a single probe may be insufficient, especially as alternative pathways may replace the function of the targeted pathway [7, 8], resulting in a false negative test outcome.
To probe the in vivo role of stress response factors in normal physiology and in solid tumors we have designed a stable 18F-labeled molecular imaging agent based on a ligand for heat shock protein 70 (HSP70).
Still, there is increasing interest in the development of molecular imaging strategies based on ligands that bind selectively to target proteins overexpressed at hypoxic sites.
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