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Molecular heterogeneity between multiple adenomas from individual FAP patients may reflect different developmental fates for these premalignant tumours.
Particularly in cancers, genome-scale studies have revealed large molecular heterogeneity between patients and even different samples from the very same tumor [ 1].
Classic clinicopathological parameters do not reveal the wide molecular heterogeneity between breast tumors and fail to accurately delineate clinical outcome [ 2].
Moreover, C-erlotinib in PET/CT could be a useful tool to identify molecular heterogeneity between tumours in the same patient.
Besides the observed molecular heterogeneity between and within the different astrocytoma types, we next aimed at the identification of core sets of genes that were commonly under- or overexpressed in different astrocytoma subsets.
Ideally, biomarkers should be assessed in tissue from relapsed patients as recent studies in other tumour types have confirmed extensive molecular heterogeneity between primary tumours and metastases (Gerlinger et al, 2012).
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In this study we have examined both a class 1 (e1368) and a class 2 (e1370) allele of daf-2 for molecular heterogeneity over lifespan between individual nematodes.
These data indicate a low prevalence of nasal MRSA carriage but obvious evidence of molecular heterogeneity of S. aureus isolates between CR and HW at Sun Yat-Sen University, Guangzhou.
Coupling the HPLC separation according to the chemical composition with size exclusion chromatography (SEC) enables to reveal for the first time the complete molecular heterogeneity, i.e. the relationship between the chemical composition distribution and the molar mass distribution of EPDM.
For FFPE samples, there was no clear clustering distinction between naevi, primaries and metastases, perhaps reflecting the molecular heterogeneity of melanoma.
Many other genes demonstrate recurrent mutations at lower frequencies (between 1% and 8%), reflecting the broad molecular heterogeneity of breast cancer [ 1, 17- 20].
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