As expected, biological processes and molecular functions requiring histone activity, including nucleosome assembly (0006334), nucleosome organization (0034728), DNA packaging (0006323), chromatin assembly (0031497), DNA binding (0003677), and nucleic acid binding (0003676), are highly ranked.
Therefore, computational methods that can predict the molecular functions are required (Kinoshita and Nakamura, 2003; Thornton et al., 2000).
Further validation of our results in larger populations and additional studies evaluating their molecular function are required.
Despite their unique molecular/structural features, functions required for formation of their cognate molecules/structures are highly conserved.
The realization of molecular nanodevices with advanced functions requires the development of new approaches to construct desired molecular nanostructures.
A solid understanding of the molecular mechanisms of biological functions requires systematic profiling of dynamic interactions between biomolecules.
Thus, current results showing increase in mortalin in Ashwagandha treated group indicate role of mortalin in cytoprotective mechanism induced in glial cells and elucidation of molecular mechanism(s) of these functions requires further studies.
Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular properties, which is non-trivial.
