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These terms describe where a gene product is located or its association with cellular components, they describe its activity in biological processes and the molecular functions it performs during the biological processes.
In parallel with the emergence of non-classical molecular functions, it has become apparent that snoRNAs might play a role in human diseases, including cancer [ 17, 135, 136].
This behavior is characterized in three orthogonal categories: the cellular components it belongs to, the biological processes it is involved in and the molecular functions it performs.
Judging from their molecular functions, it is clear that Parkin-mediated ubiquitylation and phosphorylation by PINK1 are key events in disease pathogenesis, but the details are still largely unknown.
Consequently, the actual repertoire of the urancestor inferred from FSFs in modern proteomes, while relatively complex in the number of molecular functions it embodies, is closer to the simple progenote model and distant from the complex cenancestor model.
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By application of the Tight-binding method based on the density functional theory for molecular potential functions, it is possible to analyze and optimize the nucleation and layer growth mechanisms of elementary layer substrate systems.
Prx1 is known to have two oligomeric states with different molecular functions: In its dimeric state it shows H2O2-degrading (peroxidase) activity, but switches to chaperone activity after formation of a decamer, consisting of five dimers, in response to heat stress or oxidative stress [ 36, 37].
Vice versa, the clusterings on higher levels are much more specific but they cover only a few proteins out of all: the minimal specificity of any cluster regarding categories from biological processes is 0.98, for molecular function categories it is 0.99, and for cellular component categories it is 0.99.
According to the following measures the clustering computed by LInCS lies between the two levels: it covers 880 proteins instead of only 609 in level 4 but it is already almost perfectly specific: for all clusters the minimal specificity concerning biological process categories is 0.99, for all molecular function categories it is 1.0 and for all cellular component categories it is 0.99.
The intron #1 sequence may have a common molecular function as it is abundantly found in several mRNAs and in multiple introns within an mRNA, however, it does not exhibit a special secondary structure or display a significant open reading frame.
This property might be used by these repeats to perform their elusive molecular function, be it related to DNA or to RNA metabolism.
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