Similar UVR exposure can also affect key molecular functions including collagen fibril assembly and protease susceptibility [65, 68, 69].
The methylation PSF includes 48 methylated sites in 44 genes coding for basic molecular functions, including transcription regulation, DNA binding, cytokine, and transferase activity.
Gene Ontology (GO) analysis using GoSurfer revealed major categories for genes significantly altered by cocaine, which demonstrated changes in gene expression related to specific molecular functions, including angiogenesis, apoptosis and cell death, cell adhesion, neurogenesis and axon guidance.
Molecular functions, including those of autophagy related-proteins, sometimes differ according to the organ or cell type, such as somatic versus hematopoietic cells.
The most positively correlated network to EAE susceptibility and severity, gene network A (Fig. 2), associated with molecular functions including T cell-mediated immune mechanisms.
These include proteins that are involved in a variety of different molecular functions including vesicle trafficking, purine metabolism, transcription/chromatin regulation, cytoskeletal function, and RNA metabolism.
CircRNAs have a more stable molecular structure that can resist to exoribonuclease comparing to those linear ones, and their molecular functions include microRNA sponge, regulatory roles in transcription, mRNA traps that compete with linear splicing, templates for translation and possibly other presently unknown roles.
That is, the molecular functions included an over-representation of transcriptional functions such as transcription factor regulation and DNA binding.
Other highly enriched molecular functions include chemokine and cytokine activity/receptor binding (8 of the top 15) and peptidase activities.
Over-represented molecular functions included ATP binding, nucleotide binding, lipoic acid binding, oxidoreductase and L-lactate dehydrogenase activity.
Similarly, over-represented molecular functions included actin-binding (GO 0003779), calcium ion binding (GO 0005509) and phospholipid binding (GO 0005543).
