The gene expression signature of post-septic BMDC provided a molecular and functional profile based in GEO.
Although astrocytes are often classified as a population of cells, glial subsets can display diverse molecular and functional profiles (Matthias et al., 2003; Nimmerjahn, 2009; Regan et al., 2007).
Native atrial and ventricular CMs exhibit distinct molecular and functional profiles essential for their diverse physiological roles in the heart, and hPSC-CM cultures enriched in these subtypes would have significant added value in drug response assays.
One possibility is that endogenous DDX3 is preoccupied in a molecular complex other than the IPS-1 pathway since DDX3 is involved in almost every step of RNA metabolism and its localization affects its functional profile [18], [30].
The Onto-Express module helps to recognize functional profiles (using gene ontology terms) for the categories: biochemical function; biological process; cellular role; cellular component; molecular function, and chromosome location [ 20].
Results of functional profiling were represented by two graphs for each considered GO category: biological process, molecular function and cellular component.
Functional profiling of the cluster involves the statistically enriched annotations of biological processes, the cellular component, molecular functions, and related pathways.
Functional profiles for the differentially expressed genes were derived for each of the GO categories: cellular component, molecular function and biological process.
From the microbiota side, there is big room to study molecular genetics mechanisms by which how the physiology and pathology relevant microbiota taxonomic and functional profiles are regulated.
Early descriptive work in cancer functional profiling proved difficult to interpret or act on, and only a detailed understanding of molecular activities within the complex, mixed cellular population of a tumor allowed the creation of effective targeted therapies.
