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Recent studies in animal models combining behavioral, molecular, functional imaging and optogenetic techniques reveal maladaptive, dysregulated gene expression and impaired stress-neurocircuit function across multiple brain regions as sources of individual stress-vulnerability.
Molecular functional imaging may guide individual treatment doses, thereby decreasing drug toxicity side effects or avoiding ineffective treatments in drug-resistant tumours and reducing economic health costs of potentially ineffective therapy in individual patients.
Quantitative molecular functional imaging, in conjunction with quantitative structural imaging, will be the future of 'personalised radiology,'personaliseded oncology,'personaliseded medicine,' and of oncologic research in the 21st century and beyond.
Molecular functional imaging (MFI) has given a newer insight to the medical imaging and has diversified the role of imaging in the field of the translational cancer medicine and has an indispensible role to play in screening, early diagnosis, staging, predicting prognosis, therapy delivery, therapy monitoring and follow-up.
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In the ESR Statutes, radiology is described as 'diagnostic and interventional radiology, biomedical, molecular and functional imaging'.
In addition, novel molecular and functional imaging probes targeted angiogenesis have been intensively developed and evaluated (reviewed in [53]).
Molecular and functional imaging can play important roles in shaping and selecting treatments to match this landscape.
With the current molecular and functional imaging techniques all kinds of antitumour activity can be detected such as changes in receptor expression and tumour perfusion.
The recent introduction of simultaneous hybrid PET-MR systems for combined molecular and functional imaging could be of great use in terms of understanding underlying cardiac pathophysiology and improving cross-modality validation.
Our purpose in this review is to examine the roles of molecular and functional imaging, within the context of the tumor microenvironment, and the feasibility of their applications for precision medicine and theranostics in humans.
Molecular and functional imaging can improve the diagnosis and staging of cancer and hence improve treatment.
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