Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs and the paucity of ligands with specific signaling effects.
Alternative splicing plays an important role in generating molecular and functional diversity in multi-cellular organisms.
The molecular and functional diversity of G protein coupled receptors is essential to many physiological processes.
GPCRs display molecular and functional diversity, such as the type of G-protein signaling pathway associations, different levels of constitutive activity, and different signaling responses due to different ligand-selective conformations [4], [5].
Panzea is a database dealing with molecular and functional diversity in the maize genome.
The vascular endothelial growth factor (VEGF) family includes seven members which are structurally homologous, but display molecular and functional diversity [ 58, 81].
Our data reveal that the genomes of animals and unicellular holozoans considerably increased the molecular and functional diversity of their HECT system compared with other eukaryotes.
This data suggests that the molecular and functional diversity contained in the vast native landraces remains to be explored, and that large-scale transcriptional sequencing of a presumed ancestor of the modern maize varieties represents a valuable approach to characterize the functional diversity of maize for future agricultural and evolutionary studies.
The recently sequenced genomes of 12 Drosophila species [ 18], the mosquito A. gambiae [ 19], the silkworm B. mori [ 20], the honeybee A. mellifera [ 21], and T. castaneum [ 18] have renewed interest in molecular and functional diversity in the insect nAChR alpha6 gene.
The small, but important, function of comparing co-expressed genes may provide clues to the molecular functional conservation or diversity between orthologus genes, particularly Poaceae family genes.
