It is essential that we learn to recognize and accordingly weigh such functional determinants to predict the outcome of natural or engineered perturbations at the molecular level.
In Section 2, we review the properties of functional determinants and linear functionals.
In recent years, there have been numerous advances in understanding the molecular determinants of functional kidney injury after ischemic and/or toxic exposure.
The precise molecular determinants for functional RNA recognition by RIG-I have been well characterized through structural, biochemical and cell-based approaches (Schlee et al., 2009; Luo et al., 2012b; Kohlway et al., 2013; Goubau et al., 2014).
Alternatively, clear host or tissue determinants may still remain hidden within the substantial group of proteins for which we currently have no clear molecular function, or in uncharacterised functional RNAs.
Our findings raise questions about the molecular determinants of ARS function in these three species.
The HD-PTP UBAP1 HD-PTP UBAP1entifiestructureecular determidentifiesthe interaction and provides a molecular basis for the specific functional cooperation between HdeterminantsAP1.
The major molecular determinants that are known to influence the functional activities of the neuraminidase (NA) glycoprotein are the enzyme active site, the stalk length, the sialic acid binding site also referred to as the hemadsorbing site (HB), and potential glycosylation sites.
Therefore, we investigated in an isogenic model of cisplatin resistance the molecular determinants for rhTRAIL sensitivity, the mechanism of synergy between cisplatin and rhTRAIL and the role of functional p53 in this synergy.
The results of microarray analyses indicated possible molecular determinants of resistance, and to corroborate these conclusions, real-time qPCR analysis of genes selected by their functional roles and expression profiles were performed on individual samples (n = 4/n = 6).
