This difference is most significant in those molecular functional classes that are frequently reported to interact with their respective domains, but weak in functional groups that are rarely reported to interact with their respective domains.
When the predictive quality of GO classes was investigated in relation to groups of wider functional categories given by the hierarchical nature of GO, we found that 53 of the 63 GO molecular function classes located under GO 0003824: catalytic activity were significantly predicted (P<0.0020).
The computational approach to antimicrobial agent discovery and design encompasses genomics, molecular simulation and dynamics, molecular docking, structural and/or functional class prediction, and quantitative structure activity relationships.
In the case of Molecular Function, the predominant functional classes belong to enzyme activity.
The annotation allowed us to assign the BDTs into three functional classes: molecular functions (MF), cellular components (CC), and biological processes (BP).
The molecular pathways and functional classes to which individual modifiers belong appear strikingly similar for each individual disease-related protein (Table 3 and Table 1 of Supporting Information).
This has been constructively demonstrated in previous studies that have categorized the molecular entities into functional classes [ 5] or mechanical instructions [ 6].
We use molecular signatures in particular genes to explore adaptation of the functional network, seeking whether human adaptation at the molecular level of the innate immunity system has occurred preferentially on some functional class or classes (with more plasticity to respond to the pathogenic pressures) or in specific positions of the network structure.
Each functional class is further subdivided into subtypes exhibiting distinct physiological, morphological, and molecular properties (Lallemend and Ernfors, 2012; Usoskin et al., 2015).
Enriched GO terms in this functional class come both from "biological process" ("response to DNA damage stimulus", "DNA repair", "cellular DNA metabolic process") and "molecular function" ("DNA photolyase activity", "damaged DNA binding") (Figure 4, Figure S1, Table S3).
