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The GO annotations were further refined into biological processes, cellular components and molecular functional annotations.
In addition, all RBPs were classified into three major functional groups according to their molecular functional annotations provided in NCBI: (i) splicing factors, (ii) 3′ UTR/poly(A) binding factors and (iii) microRNA binding factors.
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These genes fell into several interesting categories (ten without molecular functional annotation).
Human disease is closely correlated with human molecular complexes, and molecular complexes are widely applied in molecular functional annotation and disease prediction.
We have used GO molecular function annotations of the proteins linked to each fragment for functional descriptions of fragment clusters (Figure 1E).
When the less reliable electronically inferred functional annotations were excluded, 30% of the ArboreaSet contigs were assigned molecular function annotations.
We conclude, on the basis of our molecular and functional annotation data, that CPE failure in AD exists.
At the level of protein class or Gene Ontology (GO) molecular function annotation, we only have 13,591 genes with any experimentally based functional annotations and, of the 8600 GO molecular function terms, most have very few associated gene products.
Nonetheless, our molecular data and functional annotations largely corroborate previous morphological, biochemical and (patho-) physiological studies on the same subject.
IPA-Core analysis integrates experimental data with its knowledge base containing a repository of molecular interactions and functional annotations extracted from selected, manually curated, literature sources and databases.
The mapping of gene ontology functional annotation terms onto the non-redundant full length sequences resulted in 901 of our feline cDNA sequences becoming associated with 647 unique gene ontology molecular function annotation terms resulting in 3219 annotation-gene relationships.
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