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JW carried out the molecular functional analysis of IGFBP3 and IGF1 signalling and helped to draft the manuscript.
Conservative annotation is an approach that has been widely used in functional genomics and molecular functional analysis but may not fit the need for evolutionary genomic study.
Further molecular functional analysis of SIPA1 and its SNPs in the human population is needed to properly elaborate the function of this gene and its potential as breast carcinogenesis marker.
Finally, we suggest that miR23b and NOX4 antibody show potential diagnostic usefulness, and molecular functional analysis of miR23b in neuropathic pain may provide attractive therapeutic tools for the treatment of pain by the regulation of NOX4 expression.
Furthermore, the most prominent GO categories of molecular functional analysis were "transcription factors" and "nucleotide binding proteins"(supplementary table S7, Supplementary Material online) and the major localization signal comes from the nucleus in the cellular component analysis (supplementary table S8, Supplementary Material online).
In this study, we performed molecular functional analysis to study the expression of Klotho in the intervertebral disc and to elucidate the signal crosstalk between Klotho and Wnt signaling; this crosstalk is attracting attention as a potential trigger for degeneration in the intervertebral disc.
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The relatively few examples of such convergent changes are based largely on molecular and functional analysis of proteins with well-defined structures and functions; consequently, the inference of convergent adaptive polymorphism or divergence allows plausible arguments to be made regarding the phenotypic adaptive effects of particular mutations in different lineages.
Gorry, who continues to collaborate with Gray, writes that "Lachlan became expert at molecular and functional analysis of HIV-1 envelope glycoproteins, and he showed how these glycoproteins evolve in viruses isolated from patients during disease progression, and also within the brain".
Our molecular and functional analysis on the two zebrafish IGFBP-2 genes suggests that they have undergone subfunctionalization partitioning by evolving distinct gene expression patterns, while their protein functionality remains largely unchanged.
By providing a molecular and functional analysis of ATIP3, the present study brings a major contribution to the characterization of MTUS1 gene products and to the identification of potential driver mutations that may lead to a loss of function of the ATIP3 protein in cancer.
Morphological, molecular and functional analysis of these EV-riched biofluids could be conducted and expand our understanding of cancer risk and development.
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