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A total of 156 DEGs were assigned to three gene ontology classes: biological process, cellular component and molecular function, with 509 functional terms.
Combining empirical measurements of impairments in molecular function with computational neuronal modelling integrates different scales of evidence.
The majority of grapevine PKs that arose by tandem duplication were enriched in two of the three GO categories, namely, biological process and molecular function, with only approximately 10% of tandemly duplicated PK genes enriched in the GO category of cellular component (Fig. 3a).
In a second assessment of model performance, we showed that GCI annotation levels correlated well with Gene Ontology terms of molecular function, with no correlations observed for the biological process and cellular component categories.
The table ranks the gene enrichment in biological processes, cellular component and molecular function with corresponding GO IDs.
The following GO terms were selected: GOTERM_BP_ALL (biological process), GOTERM_CC_ALL (cellular component) and GOTERM_MF_ALL (molecular function), with classification strategy 'high'high
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Molecular function analysis revealed human secreted proteins had 39 types of molecular functions with a total of 3,059 GO IDs.
These groups encompassed a variety of molecular functions with no significant deviation from the composition of the overall dataset (Additional file 9).
When A. thaliana proteins were annotated with Gene Ontology (GO) terms, paralogous proteins with non-conserved disordered segments were associated with 18 biological processes and 10 molecular functions with corrected p-values < 10E-5.
Tests for significant categorical enrichment were performed using the rank biserial correlation on biological processes and molecular functions with at least ten genes and pathway components with at least five genes measured in our study.
It is notable that while the individual sites reported to be ageing associated differ to some extent between studies, the results regarding their locations in the genome and the molecular functions with which they are associated are more uniform.
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