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Diagrams contain terms taken from the Biological Process and Molecular Function ontologies.
Seven "Molecular function" ontologies and 4 Pfam domains were depleted from secretome.
Yet Gene Ontology enrichment in either the Biological Process or Molecular Function ontologies does not lead to statistically significant enrichment.
Consistently, ribonuclease T2 (GO:0033897) and RNA methyltransferase activity (GO 0008173) are molecular function ontologies enriched in the secretome.
Monooxygenase activity (GO 0004497) and monophenol monooxygenase activity (GO 0004503) are molecular function ontologies enriched in the secretome.
Consistently, 15 "molecular function" ontologies directly or indirectly related to sugar metabolism are enriched in the secretome.
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Functional enrichment analysis of the Molecular Function ontology was performed using the Classification SuperViewer tool of the Bio-Array Resource for Arabidopsis Functional Genomics, BAR (Toufighi et al., 2005).
When significant probes are organized according to molecular function ontology with a fold change threshold of two, ontological categories of differentially abundant transcripts emerge by EASE analyses (Tables 2 and 3).
Since we focused on the recurring patterns of the functional attributes of protein interactions, we used the molecular function ontology.
In the molecular function ontology (Fig. 6b), overrepresented GO categories can be divided into four clusters.
The network, enriched with molecular function ontology, was analyzed using Network Based Inference (NBI).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com