Of these 4,527 ESTs, 78% (3,512) have an associated biological process description, 90% (4,071) have an associated molecular function description, and 65% (2,960) have an associated cellular component description.
Finally, sub-molecular function description open the doors for further non-deterministic simulation, where neoformed pieces of molecules can carry their own new function.
In "molecular function", the largest description was "catalytic activity" with 17,260 contigs followed by "binding" and "transporter activity".
The Gene Ontology annotation of transcripts helped classify functional descriptions into three principal ontologies: molecular function, biological process and cellular component.
Child, or descendant, terms of the top level or "root" node (called "molecular function") become increasingly specific in their description of protein function.
The original GO description defines its molecular function as a generic "GTP binding" property but the subunit was correctly assigned the more specific guanyl-nucleotide release factor activity by ARGOT, PFP and Blast2GO.
The identification, group membership, and brief description of associated molecular function or biological process of the 54 genes associated with neurobiological processes for the M and L data set are given in Additional file 1.
We have used GO molecular function annotations of the proteins linked to each fragment for functional descriptions of fragment clusters (Figure 1E).
Three structured ontologies were chosen to allow the description of biological process, molecular function, and cellular component.
