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The cellular component, biological process, and molecular function classifications of the honey bee sequences are shown in Table 2.
Analysis is displayed referring to "biological process" and "molecular function" classifications; "cellular component" is not reported due to the absence of particular enriched subsets.
Establishing molecular function classifications with PANTHER pathway analysis [29] reveals that the primary interactions of mature β2∗ nAChRs occur with structural proteins that are part of, and regulate the growth and assembly of, the cytoskeleton.
Reported protein-protein interactions, protein molecular function classifications, biological processes and sub-cellular localizations were according to the Hprd dataset [ 37], which is a non-redundent manually curated protein database, downloaded in November 2005 from.
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Among the 55 genes with at least 2-fold increased expression, assignment to GO groups was possible for 43 using the biological function classification, 41 using the molecular function classification, and 31 using the cellular constituent classification.
Among the 50 genes with at least 2-fold reduced expression, assignment to GO groups was possible for 33 using the biological function classification, 41 using the molecular function classification, and 29 using the cellular constituent classification.
The cell component and molecular function classification identified 12 and 2 genes, respectively, to extracellular function.
The GO molecular function classification showed that the differential genes were associated with growth.
Transporter and hydrolase activities, as well as protein, ion and heme binding also were overexpressed regarding molecular function classification.
We calculated overrepresented GO terms for cellular component, biological process and molecular function classification systems and then merged results.
Among the molecular function classification class, the enzyme activity, binding activity, hydrolase activity, transferase activity, molecular function and nucleotide binding categories included the majority of detected matches.
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