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These two Lasker winners' discoveries are beginning to help provide a molecular framework for understanding normal functions like learning and memory as well as some of the most severe mental illnesses, including schizophrenia.
These studies establish a molecular framework for the engineering of this versatile biocatalyst.
In summary, the structural characterization of the DAXXDHB domain in complex with ATRXDBM provides a molecular framework for understanding the interaction between DAXX and ATRX.
Our results provide a molecular framework for understanding PARP inhibitor action and, more generally, allosteric control of dynamic, multi-domain proteins.
The structures also provide a molecular framework for understanding the functional contributions of trans-acting elements that facilitate intersubunit crosstalk in response to DNA binding and ATP hydrolysis.
Our findings provide the first structural view of the nGR subunits and a molecular framework for understanding the architecture, conservation, and function of nGRs.
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De novo design of supersecondary structures is expected to provide useful molecular frameworks for the incorporation of functional sites as in proteins.
Neither the molecular frameworks for the non-canonical pathways have been defined nor has the role of CKIε in ovarian cancer and its clinical utility been reported.
It also includes compound and document counts and the molecular framework breakdown for the compound sets.
Understanding the genomic location of these genetic control points may provide insight into the genetic and molecular framework responsible for enabling the trait.
In the GS ranking we see the elastase ELNA rising from 49 to 20 but the kinase MAPK14 dropping from 4 to 14. Thus, for an individual target the tractability depends significantly on the molecular framework level used for ranking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com