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We are interested in discovering the specific molecular features underlying the functions of insect nervous systems.
Because it is an untargeted approach that enables novel gene discovery, the subtraction technique is especially appropriate for characterizing molecular features underlying the suite of arctic plant specializations.
However, intrinsic molecular features underlying this function or mechanisms regulating the specific involvement of the H1.2 isoform are not known and are primarily investigated in this study.
To try to understand the molecular features underlying the different inhibitory efficiency of quinalizarin against CK2 tetramer with respect to CK2 α, a two-step computational study has been performed.
To shed light on the molecular features underlying the remarkable selectivity of quinalizarin, a multiple alignment of the human kinome has been performed), highlighting the amino acids involved in the quinalizarin binding motif, according to the crystallographic data available (PDB codes: 3FL5 [ 10], 3Q9Z, and 3Q9Y [ 29]).
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Given the observations of impaired learning and memory in the Tc1 mice, and the importance of hippocampal function and the MAP kinase pathway in learning and memory (25), perturbed stoichiometry among pathway components presents one possible molecular feature underlying the deficits.
To investigate the molecular and structural features underlying the differences in HIV-1 and HIV-2 biology and human infection, we have analysed the C2-V3-C3 envelope region from a significant number of HIV-1 and HIV-2 infected patients living in Portugal and worldwide.
Key molecular and histochemical features underlying age-dependent phenotypic alterations of the human skin include decreased collagen production in dermal fibroblasts, leading to the fragmentation and disarray of collagen fibrils in the dermis.
In recent years, features underlying the heterogeneous behaviour of breast cancer have been addressed with the help of modern methods of molecular pathology and histopathology (van de Vijver et al, 2002; Rakha et al, 2008; Geyer et al, 2009).
To investigate sex differences in molecular features that may underlie normal LM and perturbations that may contribute to impaired LM in DS, we describe here expression levels of ~100 proteins in the hippocampus, cortex, and cerebellum of cohorts of male and female control mice and their age- and sex-matched trisomic littermates from the Dp10 line.
This method appears very simple, but cumulative evidence found that underlying molecular features are different in right- and left-sided colon cancers.
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