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Inclusion of the basal cell-specific transcription factor p63, known to be essential for the proliferation potential of stem cells in stratified epithelium [88], helps to explain why airway basal cells exhibit a number of molecular features typical for the squamous phenotype.
The group of Gabellini developed a murine model of FSHD overexpressing the FRG-1 gene that resembled histological and molecular features typical of the disease [ 3].
The resulting tumors display histopathological and molecular features typical of ALK human non-small cell lung cancer (NSCLC) and respond to treatment with ALK inhibitors [ 8]; using a well-established mouse model of lung cancer, T. Jacks group functionally characterized a panel of candidate tumor suppressor genes by inducing specific knockout mutations by the CRISPR/Cas9 method [ 9].
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This protein, that we named isomin, shares with cytoplasmic IFs typical molecular features and in vitro assembly properties.
gambiae genome had typical heterochromatic molecular features: low gene density and high coverage of TEs and SDs.
This new protein, we named it isomin, is a component of the intestinal terminal web and shares with IFs typical biochemical properties, molecular features and reassembly capability.
Both the immunohistochemical and molecular features observed in the ACC are typical of BRCA1-associated breast cancers and suggest an involvement of the patient's germline mutation in the disease.
The deduced SasC sequence consists of 2186 amino acids with a molecular mass of 238 kDa and has features typical of Gram-positive surface proteins, such as an N-terminal signal peptide, a C-terminal LPXTG cell wall anchorage motif, and a repeat region consisting of 17 repeats similar to the domain of unknown function 1542 DUF15422).
Thus, gene expression analysis might help to identify a subgroup of G2-LAC, which already reveals the molecular features of poorly differentiated LAC but lacks typical histomorphological dedifferentiation.
The filters involve the most typical molecular fragments (functional groups) together with variation intervals of spectral features typical for these fragments.
The clinical and molecular features of the cohort represented an inherent distribution that is typical for CRC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com