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The researchers made a large collection of them by modifying molecular features such as the chain length to get the ones with the properties they wanted.
Immunorecognition of RNA depends on certain molecular features such as length, double- versus single-strand configuration, sequence motifs, and nucleoside modifications such as triphosphate residues.
The atom-type, group-type, bond-type and single-atom E-state descriptors encode information on specific molecular features such as atom and bond types associated with important functional groups.
Thus, finding molecular features such as extracellular mRNAs of unfavorable genes, which identify patients with poor outcome within a low IPI, is an important objective.
Furthermore, patient-specific molecular features such as polymorphisms of detoxifying enzymes can affect the metabolism of anticancer drugs and thus can play a role in both efficacy and toxicity profiles.
While we are still far from fully understanding the molecular mechanisms underlying these disorders, certain specific molecular features such as increased percentage of heteroplasmy, relatively lower homology at breakpoints, and a decreased frequency of the common deletions, may play a role in the severity and earlier age of onset of mtDNA deletion syndromes.
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CurlySMILES modifies the SMILES language by including a novel format to encode molecular details and extra-molecular features such as non-covalent interactions and attachment to a biomolecule as well as the surface of a substrate material or nanoparticle.
Powerful new genomic technologies, such as next-generation sequencing (NGS), promise to unlock the molecular features of such samples and inform the linkage of genotype and phenotype.
Recognition and binding to specific lipids play a central role in targeting reactions, but it remains difficult to analyze the molecular features of such protein-lipid interactions.
As for PUC we could show in the largest series described to date, that on the one hand this subtype of UC accumulates prognostic unfavourable molecular features, like such as the loss of CK20, a high proliferation index and p53 accumulation, and as well as on the other hand exhibits characteristic molecular features, like such as a complete loss of membranous E-cadherin expression [ 4].
The technique uses explicit description of atom locations with no adjustable potential parameters and thus allows parametric study of molecular structural features such as non-planar aliphatic rings, irregularly-shaped polyaromatic cores, and methyl groups.
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