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This work would be an example for next meta-analysis works aiming at identifying specific common molecular features linked with biotic stress responses in other specialty crops.
The paucity of cytogenetic and molecular features linked to T-LBL clinical response presents intriguing opportunities for study.
We investigated molecular features linked to angiogenesis, cell invasion and epidermal growth factor receptors on the primary tumour (pMBL), metastases (M1 and M2) and SLC.
In summary, we used the genomics data described above, together with a large-scale tissue platform, to pinpoint molecular features linked to the early occurrence of ESCC.
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However, it was unclear if cells derived from these two pluripotent stem cell sources demonstrate similar molecular and cellular features linked to their biological function.
We correlated the first distant metastatic site with 18 selected primary tumor molecular features that are linked with the breast cancer molecular subtype, epithelial-mesenchymal transition, myoepithelial or stem cell-like features, or are a potential drug target.
Due to challenges posed by the clonal nature of MAE, very little is known about its regulation; in particular, no molecular features have been specifically linked to MAE.
Since clinical response data for targeted treatments are very limited, cell line models have become an increasingly important tool for research into the molecular basis of different cancers and linking molecular features to phenotypes such as drug response [ 16, 17].
This suggests that the subtyping presented here allows a more fine grained subdivision of CRC samples which is likely to have greater utility at linking molecular features to pharmacology.
The study by Blaess et al. [ 4] clearly shows that the ability to mark different cell lineages in the ventral midbrain will be valuable for the generation of a more comprehensive lineage map that will also help to link molecular features and phenotypes in different mouse mutants to mechanisms that are essential for DA neuron subtype development.
Taken together, our results demonstrate the usefulness of metabolomic profiling of genetically diverse varieties for linking quality traits with molecular features.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com