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Here, we show that a chemical cocktail enables the derivation of stem cells with unique functional and molecular features from mice and humans, designated as extended pluripotent stem (EPS) cells, which are capable of chimerizing both embryonic and extraembryonic tissues.
Molecular features from chemicals, proteins, and DNAs/RNAs could be easily calculated through BioChem tool, BioProt tool and BioDNA tool, respectively.
In contrast with CH1641, PrPres was also consistently detected in the spleen of mice infected with six natural "CH1641-like" scrapie isolates, but then showed clearly different molecular features from those identified in the brains (unglycosylated PrPres at ∼18 kDa with removal of the 12B2 epitope) of ovine transgenic mice or of sheep.
Accumulating evidence suggests that proximal colon cancers differ in clinical, pathological, and molecular features from distal cancers.
This approach retrieves molecular processes integrating molecular features from more than one species, by this providing molecular process models underlying cooperative phenomena.
In contrast, MSI-L colorectal tumors have not been shown to differ in their clinicopathologic features or in most molecular features from microsatellite stable (MSS) tumors.
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A number of European countries have subsequently reported cases of atypical scrapie, similar to previously published cases from Norway, which have pathological and molecular features distinct from classical scrapie.
Thus, VSELs possess several molecular features expected from PSCs.
11 13 Tumour cells are broadly sensitive to HAMLET, reflecting shared molecular features resulting from oncogenic transformation.
These mice thus showed PrPres molecular features indistinguishable from those in Tg110 mice infected with C-like features.
Otherwise, these could represent samples with molecular features distinct from the other members of their assigned clusters.
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