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Label-powerset revealed important molecular features for selective or polyspecific inhibitory activity.
These data identify molecular features for patient stratification and uncover a potential targeted treatment approach for MYC-driven SCLC.
Label-powerset revealed important molecular features for selective or polyspecific inhibitory activity, while binary relevance and classifiers chain allow for more predictive models.
The models reveal important molecular features for specific or polyspecific inhibitory activity such as SlogP, the number of donors and acceptors of H bonds, the number of aromatic atoms and the length of the maximum single bond chain.
In order to gain insight into molecular features for alkaline adaptation, we compared BSP165 MAN with previously reported GH5 β-mannanases.
The x-ray crystal structures of the TTR inhibitor complexes presented here illustrates the key molecular features for inhibitor binding and provide the structural basis for the stabilization of the native tetrameric TTR.
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Such evolutionary convergence among distantly related silk spinning species suggests that large size is a critical molecular feature for silk fiber mechanical performance.
This suggests that the fundamental molecular feature for members of this family is being a l ipid transfer protein a nchored at a m embrane contact site (hence 'LAM'LAM
Control transfected MCF10A cells and MCF10A-Akt1 cells were cultured in coated plates under medium conditions as shown in Figure 4 and subsequently analysed for molecular features of apoptosis.
Known molecular features characteristic for BRCA1-mutated breast tumors are 1) a high degree of genomic instability due to homologous recombination (HR) deficiency [ 18], 2) a distinct pattern of genomic aberrations [ 19- 22] 3) a high frequency of TP53 mutations and 4) a high incidence of complex, protein-truncating TP53 mutations [ 10, 23].
There are several known molecular features characteristic for BRCA1-mutated breast tumors: 1) increased numbers of genomic aberrations, 2) a distinct pattern of genomic aberrations, 3) a high frequency of TP53 mutations and 4) a high incidence of complex, protein-truncating TP53 mutations.
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