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Several investigators [ 35, 36] have queried whether molecular expression scores provide discrete information to those routinely provided by single or composite pathological prognostic tests already routinely provided.
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The molecular expression was scored as positive if >10% of cells had moderate-to-strong staining.
Active research is currently ongoing on molecular features and gene expression scores combined with standard clinico-pathological criteria to tailor extended endocrine therapy [ 115].
Meanwhile, it is appropriate not only to suggest caution in the application of molecular features and gene expression scores for tailoring extended endocrine therapy but also to encourage continuous research.
The first part specifically focuses on ILC transcriptomic features by reviewing the intrinsic molecular subtypes, the application of gene expression scores for the prediction of recurrence, and the identification of gene expression subtypes.
Comparison of the TNF-α expression scores in the lung.
Expression scores for each probe-set were defined as the median of the probe expression scores.
A score of 0 was defined as negative expression, scores 1 4 as "weak expression," scores 5 8 as "moderate expression," and scores 9 12 as "strong expression" [ 21].
Positivity of molecular expression was compared between the groups.
Comparison of NF-κB expression score in the lung.
Comparison of IL-6 expression score in the lung.
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