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These results imply that even though chicken and alligator scales share some morphological similarities, their molecular expression profiles are distinctly different.
Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to sub classify human tumors and tailor a treatment to the individual patient.
Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient.
To evaluate the effects of STAT3-CKO on the appearance and various molecular expression profiles of astrocytes in vitro, we used primary astrocyte cultures that are over 95% GFAP-expressing cells [21], [22].
Distinct molecular expression profiles distinguishing between good and bad prognosis in RCC were identified [ 15- 26].
For example, basal like cancers have distinct molecular expression profiles and histological differences when compared with the luminal type [ 42].
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Understanding these complex cellular responses requires the detailed analysis of global molecular expression profiling.
Much of our current knowledge of the molecular expression profile of human embryonic stem cells (hESCs) is based on transcriptional approaches.
Tissues were embedded in Tissue Tek, frozen on dry ice, and sectioned at 16 (for molecular expression profile analysis) and 30 μm (for cell imaging).
Postnatal P21 brains (for molecular expression profile analysis) were fixed by transcardiac perfusion followed by 1 h postfixation with 4% PFA/PBS solution at 4 °C.
At cellular level, it appeared from our results that normal intestinal cells do not display the same miR profile in right and left colon, indicating that these cells do not have the same molecular expression profile.
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