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KH conducted molecular experiments, performed data collection and analysis.
MN carried out the animal and molecular experiments, performed the statistical analysis, and drafted the manuscript.
QY designed cellular and molecular experiments, performed molecular experiments, and drafted the manuscript.
HT and MS designed cellular and molecular experiments, performed cellular and molecular experiments, and drafted the manuscript.
PJM conceived of the experiments, carried out the molecular experiments, performed the comparative analyses, and drafted the manuscript.
WEM designed and carried out all of the molecular experiments, performed all of the phylogenetic analysis and wrote the manuscript.
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Recent molecular scale experiments performed with platinum and gadolinium nanoparticles, activated by 150 MeV protons, highlighted the amplification of nanosize bio-damage (Schlathölter et al. 2016).
Because profound differences between the orthologs in the susceptibility to inhibition were observed, we also analyzed (iii) if molecular docking experiments performed with modeled enzymes can differentiate or predict the efficacy of inhibitors.
JG developed markers and assays, participated in the design of the backcross panels, performed molecular genetic experiments, performed sequence alignments, and edited the manuscript.
These parameters will now be applied in molecular imaging preclinical experiments performed in our laboratory.
HS carried out the molecular and animal experiments, performed the statistical analysis, and drafted the manuscript.
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