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Recently, the potential of ribosome display for directed molecular evolution was recognised and developed into a rapid and simple affinity selection strategy using ribosome complexes to display antibody fragments (scFv).
His population genetics work on the "neutral theory of molecular evolution" was based on his conclusions that most evolution at the molecular level is the result of random processes such as mutation and genetic drift.
"Walter demonstrated that the variance in the rate of molecular evolution was statistically larger than expected under the theory of the molecular clock and, thus, the underlying assumption of "neutral" replacements in DNA or proteins was not correct.
The question of whether drift or selection plays a more important role in molecular evolution was much debated in the 1960s and 1970s; it lay at the heart of the heated controversy between 'selectionists' and 'neutralists' (see Dietrich 1994).
But Kurland and Harish further note in their JTB paper that in 1967, when Lynn Sagan published her "seductive account of the origins of eukaryotic cells through prokaryotic endosymbiosis," molecular evolution was still a baby.
A similar pattern of molecular evolution was not evident in the p53 cancer-suppressing gene.
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Unfortunately for the neutralists, the rates of molecular evolution were found to be far from uniform.
Background: Most studies of molecular evolution are focused on individual genes and proteins.
A historical overview of the study of molecular evolution is presented in the General Timeline avaliable here.
To clarify the mechanisms of molecular evolution is a most important purpose of evolutionary studies at the molecular level.
A legacy of molecular evolution is the formation of gene families encoding proteins that often serve related functions.
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