Sentence examples for molecular events found from inspiring English sources

The most frequent identifiable molecular events found in SDHB-deficient GISTs are germline and/or somatic loss-of-function mutations in any of the four SDH subunits.

As shown in Figures 4b and c, TD52 enhanced PP2A activity and downregulated the expression levels of CIP2A and p-Akt in in vivo tumor samples, mirroring the molecular events found in vitro.

- Higher rates of microsatellite instability and KRAS mutations were common molecular events found in right side colon cancer., Whereas the left side tumor were more common to be chromosomal instable and harbor more TP53 mutation.

For mechanistic studies, it may be important to find molecular events that occur in association with the clinical outcome, but are not correlated with the clinical outcome in first order.

Through the ADH French Research Network, we collected molecular data from 1358 French ADH probands and found 1111 molecular events: 1012 (91.1%) LDLR mutations in 1003 (73.9%) probands, 9 with two LDLR variants each; 89 (8.0%) APOB-p.Arg3527Gln APOB-p.Arg3527Gln.6%) probands including 2 probands also heterozygous for a LDLR mutation; 10 (0.9%) PCSK9 mutatinns in 10 (0.7%) probands.

To determine whether the molecular events observed in cell lines were also found in mice, we performed immunohistological staining and TUNEL assay of mouse tumor sections.

No association was found, reinforcing that these molecular events had a role rather in tumorigenesis than in progression of WT.

Our long term goal is to identify molecular events that control cancer dormancy and to find ways to mimic them with aim of inducing and maintaining dormancy.

Given the critical evaluation of aggressive versus not aggressive melanoma, and the potential of therapeutics, we find it imperative to learn the molecular events of aggressive melanoma.

These data suggest that molecular events responsible for mtDNA deletions in young patients may differ from those found in older age groups.

119 KIT or PDGFRA mutations are not found in gastric tumors of Carney syndrome, and the molecular events implicated in their pathogenesis are not known at present.