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From studies of Ca++-dependent exocytosis of large dense-core vesicles in chromaffin cells, it seems that initiation of the SNARE complex is the molecular event underlying the priming process and that Munc13 acts as a priming factor by opening syntaxin.
Although we can speculate that metformin-imposed suppression of signaling through mTOR and S6K1 is the pivotal molecular event underlying metformin-induced promotion of longer lifespan & healthier aging, this possibility needs to be tested directly in future studies.
113, 114 Mitotic recombination or other genetic mechanisms resulting in the loss of wild-type allele and NF1 heterozygosity may be the key molecular event underlying GIST development in NF-1 patients.
Since the cytoskeleton plays such a crucial role in controlling cell motility [ 119], altering its function through lncRNA binding may emerge as a frequent molecular event underlying cancer metastasis.
It is known that biosynthesis of secondary metabolites such as flavonoids and other UV-B absorbing phenolic compounds, which accumulate in the vacuoles of epidermal cells, is an important molecular event underlying UV-B acclimation in plants [ 12, 19, 20], including grapevine [ 17].
More refined analyses of AKAP150 knock-in mice unable to anchor protein kinase A or protein phosphatase 2B uncover an unexpected observation that tethering of phosphatases to a seven-residue sequence of the anchoring protein is the predominant molecular event underlying these metabolic phenotypes.
Similar(53)
Even if the first drug that prevents calcium leaks does not work in patients, Dr. McClellan added, the important advance is to understand the molecular events underlying fatigue.
The cellular substrate or molecular events underlying that treatment effect are unknown.
However, molecular events underlying successful RKN infection and host responses in peanut are sparsely understood.
Breeding of stress-tolerant cultivars has been hampered by the paucity of information on molecular events underlying stress tolerance.
Molecular breeding of stress-tolerant cultivars has been hampered by a shortage of information on the molecular events underlying tolerance to stress.
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