Sentence examples for molecular endpoints from inspiring English sources

Nuclear imaging techniques such as PET can be used to monitor drug pharmacokinetics and distribution and study specific molecular endpoints.

However, to our knowledge this concept has not found implementation in the increasingly applied OMICS techniques studying thousands of molecular endpoints at the same time.

Clear alterations in molecular endpoints were evident at day 2 whereas the earliest morphological effects appeared at day 4 and were most evident at day 21.

Additional efforts to improve current risk assessment strategies for EDCs include the use of advance omic technologies to aid in identifying critical pathways and molecular endpoints that can be used to define AOPs that enable prediction of biological relevant effects.

Due to the genomic resources available for zebrafish and the long experience with zebrafish in toxicity testing, it is easily possible to establish molecular endpoints for EDC effects assessment.

This review provides a comprehensive analysis of molecular endpoints that are currently being used as indices of age-related phenomena (e.g., morbidity, frailty, mortality) and proposes an approach for validating and prioritizing these endpoints.

Opitz et al. [29] had evaluated the utility of mRNA expression of TSHα and TSHβ as a molecular endpoint to detect alteration in thyroid system function, which made up the methodological limitations in characterizing the thyroidal status of the differential treated tadpoles by means of analysis of serum T4, T3 and TSH concentrations.

Furthermore, we proposed a quantitative molecular endpoints-PELI that correlated well with conventional phenotypic genotoxicity endpoints, demonstrating that the proposed quantitative toxicogenomics-based genotoxicity assay can be a promising and alternative tool for mechanistic genotoxicity screening and evaluation in vitro (data not shown).

Both aberrations are expected to affect H3K36me2 signaling and may represent alternate pathways to the same molecular endpoint.

However, toxicity evaluation, based on molecular endpoint 1/EC-TELI1.5 values, indicated that the toxicity did not always decrease proportionally and concomitantly with the disappearance of the parent contaminant.

To further quantitatively illustrate the nature of toxicity changes during the transformation of the CECs, molecular endpoint 1/EC-TELI1.5 values for the individual stress response categories were calculated and are plotted in Figure 3.