Sentence examples for molecular end points from inspiring English sources

In this study we wished to test the glucocorticoid hypothesis using Agtr1b expression and epigenetic changes as molecular end points.

Both AZA and DAC regulated molecular end points related to drug incorporation into DNA, including DNMT1 depletion, DNA hypomethylation, and induction of the DNA damage marker phospho-H2AX.

To this end, we focused on two related molecular end points, caspase 3/7 activity and detection of the caspase 3 substrate CK18.

The accompanying translational research project will contribute to find surrogate molecular end points for drug efficacy and better tailor epigenetic therapy.

There is increasing consensus that the uterotrophic estrogenicity assay should be coupled with other morphometric or molecular end points that might enhance its sensitivity.

This will allow direct testing of cause effect relationships between toxicant effects on biochemical, cellular, or molecular end points and effects on apical measures such as behavior.

This development deems the BrdUrd comet assay suitable as a molecular end point that can be measured easily, hence facilitating trial investigations of diet- or environment-related factors affecting colorectal cancer.

First, our study is the first large prospective cohort study incorporating molecular end-points for colon and rectal cancer.

The choice of the investigated molecular end-points was based on our previous experience in studies using rodents exposed to CS 20, 23– 25, 31– 31.

We confirmed that the improved in vitro selectivity of our lead compound, ELN475516 translates into improved in vivo safety in a mouse model that is sensitive to histological and molecular end-points associated with inhibition of Notch signaling.

Exploratory research studies evaluate early, molecular, nonvalidated end points but rarely follow these initial responses to long-term adverse consequences.