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These observations call for further experimental investigations to understand the molecular effects caused by mutations in aaRSs.
Based on the limited number of animals in this pilot in vivo study, we favored endpoints over additional tissue evaluation of responsive tumors to better understand molecular effects caused by HCI2509 treatment, rendering responsive tumors unavailable for additional experiments.
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Genomic-based techniques are today important tools for investigating molecular level effects caused by exposure of toxicants and other substances.
Thus, monitoring the fluorescence intensity of Ca2+ can be used to explore molecular mechanisms of biological effects caused by external stimuli or danger signals [ 23].
Being interested in developing in vitro cellular models as alternative to animal-based toxicity assays, we hypothesize that combining transcriptomics and metabonomics data improves the understanding of molecular mechanisms underlying the effects caused by a toxic compound also in vitro in human cells.
Moreover, both the drugs and the gene-silencing technique flattened some types of cancer cells, which suggests that both methods of getting rid of reverse transcriptase's effects caused similar molecular changes inside the cells.Only connectThat common anti-HIV drugs slow cancer growth in AIDS patients has been known for some time.
Collectively, our data suggest a molecular basis for the severe side effects caused by TGN1412 and impinge upon the relevance of non-human primates as preclinical models for reagents that are supposed to modify the function of human T cells.
These "naked" particles allow a systematic molecular structure-based assessment of the effects caused directly by the NP surface, including cellular uptake and hemolytic activity.
As summarised in Table 1, MRS shows many metabolic effects caused by different molecular-targeted agents, some of which could be developed as biomarkers of response in early stage clinical evaluation.
We considered a possible molecular mechanism of the overdominance effect caused by the DelR242 locus.
Radiation resistance of nasopharyngeal carcinoma (NPC) is a joint effect caused by complex molecular mechanisms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com