Sentence examples for molecular effectors mediating from inspiring English sources

Unfortunately, the molecular effectors mediating these biological responses remain poorly understood.

Furthermore, it characterizes PKG I and RGS2 as molecular effectors mediating the cross-talk between these pathways in cardiac remodeling.

A better molecular understanding of Akt isoform effectors mediating insulin metabolic control holds the promise for the development of new and specific pharmacological interventions to improve insulin action in conditions characterized by defective Akt signalling, like insulin resistance and type 2 diabetes.

The use of unbiased high-throughput methods such as splicing-sensitive arrays alone or in combination with RNAseq, to compare isoform representation in shRNA control or shRNA against SFRS3 treated cells, are likely to help identifying the molecular target(s) of SFRS3 which might be the direct effectors mediating the negative regulator phenotype of SFRS3 in the secretion of IL-1β.

The far-reaching downstream consequences of mTOR inhibition make defining the critical molecular effector mechanisms that mediate the anti-tumor response and associated biomarkers that predict responsiveness to mTOR inhibitors a challenge and priority for the field.

However, we also showed that RhoA-mediated canonical Wnt activation required RhoA downstream molecular effectors to be functional.

Cytokines and lineage-specific transcription factors are critical molecular effectors for terminal differentiation during hematopoiesis.

The molecular effectors of GBS-induced cardiac dysfunction have not been determined.

Yet, the cellular and molecular effectors of such beneficial effect remain unknown.

However, the downstream molecular effectors of caspase-11 remain to be identified.

The molecular mechanism mediating these responses is under investigation.