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GSCs do not show major changes in their pathway activation profile and most GSCs display differential activation of nodes in the same pathways, pointing to a molecular differentiation based on rearrangement of the signaling network rather than differential activation of parallel pathways (Supplementary Table S2).
Regarding the presence of genes whose differential expression profiles may provide us with a means of molecular differentiation between subtypes (i.e. candidate biomarker molecules), we found four of them PTX3, COLEC12, and PDGFRA (whose overexpression is likely indicative of an ATC phenotype) and GPR110 (whose overexpression may indicate PTC).
Phylogeny, biogeography, and processes of molecular differentiation of Quercus subgenus Quercus (Fagaceae).
Marker studies correlate the molecular differentiation of these follicles with in situ systems.
DeLeo FR, Kennedy AD, Chen L, Wardenburg JB, Kobayashi SD, Mathema B, et al. Staphylococcus aureus epidemics: molecular differentiation of historic phagetype.
The molecular differentiation of each cleft allowed us to identify Mdga2 as a potential specificity factor influencing Neuroligin-2's recruitment of presynaptic neurotransmitters at inhibitory synapses.
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Strong molecular differentiations among sub-populations were mapped to 87 chromosome regions.
One important source comes from phylogeographic studies of spatial patterns of molecular genetic differentiation among extant lineages across their geographic distributions (Avise 2000).
Thus, breast tumors in the Chinese and Caucasian groups appear to be subjected to the same molecular and differentiation processes.
Previous studies in cereals have shown significant nonrandom adaptive molecular genetic differentiation at single and multi-locus structures among micro-ecological environments [ 8, 9].
A cassette of molecular markers of differentiation was also assessed confirming the differentiation status of both cell populations (see Figure S1).
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