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Emerging technologies such as high throughput genome mapping and microchip cDNA expression arrays may further elucidate molecular differences in these different types of breast cancer.
While findings that distinct progenitor pools give rise to different types of DA neurons suggest that molecular differences in progenitors might determine the identity of the different subtypes, it is also possible that specification events take place at postmitotic stages.
RRR-γ-tocopherol treatment resulted in cleavage of PARP, caspase 3, 7, and 8, but not caspase 9. Differences in the percentage cell death and apoptosis were observed in different cell lines suggesting that molecular differences in these cell lines may influence the ability of RRR-γ-tocopherol to induce cell death.
In the same study, the type and position of TP53 mutations also differed between the two tumor types, again suggesting molecular differences in the genetic mechanisms of bladder carcinogenesis depending on underlying etiology.
To find underlying molecular differences in PRRS susceptible versus more resistant pigs, 100 animals with extremely different growth rates and viremia levels after PRRSv infection were selected from a total of 600 infected pigs.
There are molecular differences in blood RNA patterns between pigs with extreme phenotypes or with a different WUR genotype in early responses to PRRSv infection, though they can be quite subtle and more difficult to discover with conventional DE expression analyses.
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Up until now my work has indicated that neighborhood quality in adolescence and lower economic privilege coincide with increased neural vigilance and reward sensitivity, but these effects are moderated by molecular difference in the Oxytocin Receptor Gene -- a gene deeply involved in our social development.
We conclude that there is a molecular difference in the pathogenesis of lobular and ductal breast cancer.
48 Similar protein degradation experiments for KLK7, could unravel the impact of molecular differences resulting in susceptibility of arsenic-induced skin cancer in arsenicosis-endemic populations.
Canine malignant tumours appear to be a heterogeneous group of different molecular driven tumours which would benefit from a classification addressing molecular differences as in human medicine.
These molecular differences result in distinct clinical outcomes and responses to treatment.
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