Notably these include molecular differences that cause COX-1 inhibitors to produce a slight decrease, and COX-2 inhibitors to induce a significant increase, in heart attacks and strokes.
However, each cancer may represent multiple tumor types within a single histopathologic entity and it will be critical to use common criteria for molecular profiling of tumors to avoid the problem of differences caused by artifacts in expression profiling [ 48].
It is critical to use common criteria for molecular profiling of tumors to avoid the daunting problem of differences caused by artifacts.
This may be because of other perturbations (mutations) present in that tumour, tumour cell heterogeneity, differences caused by the tumour microenvironment, or because of inherent cross-talk between molecular pathways.
Sex differences caused minor variation.
Instead of construing theory relations in terms of the Nagel-Schaffner model, he identifies a key principle of inference operating in classical genetics and molecular genetics, the "difference making principle" (gene differences cause differences in phenotypes), which can be ascribed to genes in both classical and molecular genetics.
Density differences cause additional problems to aviation.
The considerable number of therapy failures may be explained by these molecular differences between cells of the primary tumor – surgically removed and histopathologically analyzed – and the remaining DTC, which may later cause tumor recurrence.
As a result, it is unclear if observed differences in rates of molecular evolution are caused by differences in regulatory architecture, expression, or perhaps result from distinct evolutionary mechanisms such as kin selection, which may operate differentially on genes associated with social behavior relative to the rest of the genome (Linksvayer and Wade, 2009; Hall and Goodisman, 2012).
The researchers are trying to nail down the specific genetic and molecular differences between the MRL mice and other strains.
