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At present, PCR-based molecular diagnostic testing predominates; however, alternative technologies aimed at reducing genome complexity without PCR are anticipated to gain momentum in the coming years.
This approach provides a surrogate that can be potentially used outside of containment laboratories as an alternative to inactivated infectious virus for molecular diagnostic testing.
Amplicon-based methods for targeted resequencing of cancer genes have gained traction in the clinic as a strategy for molecular diagnostic testing.
As a pilot study we performed comprehensive molecular diagnostic testing, including the study of the FMR1 and FMR2 repeat regions, copy number variant analysis in a collection of 50 Spanish ASD cases and mutation screening using targeted next generation sequencing-based techniques in 44 out of the total cohort.
Molecular diagnostic testing for infectious diseases, bacterial and viral, commonly depend upon PCR based methodologies.
Molecular diagnostic testing of individuals with congenital sensorineural hearing loss typically begins with DNA sequencing of the GJB2 gene.
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Molecular diagnostic tests suitable for small labs or field conditions are now available to rapidly identify MDR TB, but their implementation lags.
With molecular diagnostic tests costing much more than routine tests, insurance companies and government agencies -- which pay for most lab tests -- are expected to scrutinize them heavily before agreeing to pay for them.
And if the cancer is already advanced, molecular diagnostic tests should help doctors determine which drugs are likely to work best, thereby avoiding unnecessary treatment and further expense.There's a fundamental dilemma here.
Molecular diagnostic tests can be divided into two primary groups.
These issues are broadly applicable to any molecular diagnostic test with a dichotomous result.
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