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Overall, we established a molecular diagnosis in 63/197 (32%) individuals in our WGS series.
This self-contained device provides an opportunity to realize on-site molecular diagnosis in the future of infectious diseases such as dengue fever.
It represents a valuable strategy for enhancing the quality of routine molecular diagnosis in laboratories that use in-house designed diagnostic systems, which can conveniently be associated to the use of specific synthetic ECs.
Here we examine miRNA suitability for molecular diagnosis in NSCLC.
Taken together these account for the likely molecular diagnosis in 64% of our families.
We defined the likely molecular diagnosis in 14 of 22 families (64%).
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Furthermore, it has been successfully employed as an amplification target in molecular diagnosis (PCR) in human and animal samples, with excellent specificity, since it is present exclusively in pathogenic leptospires [ 19, 20].
In 10 out of these 12 patients, this would have resulted in a molecular diagnosis, resulting in a solved rate (diagnostic yield) of 83% (10/12 = 83%).
Lower cost, quickness, simplicity, specificity, and sensitivity make LAMP a powerful alternative for PCR in the field of molecular diagnosis, especially in developing countries.
The success of DNA expression microarrays has been followed by applications of this technology to molecular diagnosis, mainly in the fields of biology and medicine.
Ultimately, the mutations in newly identified genes will require iterative clinical examination to confirm the individual molecular diagnosis, especially in the case of allelic disorders.
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