Exact(3)
Molecular determinants regulating the activation of class B G-protein-coupled receptors (GPCRs) by native peptide agonists are largely unknown.
Moreover, several arguments advise caution before grafting NSCs in patients that include, a) evidence that glioblastoma may arise de novo from the oncogenic transformation of NSCs [1], [4], b) common molecular determinants regulating neurogenesis and tumorigenesis [5] [7], and c) generation of glioma-like lesions following growth factor stimulation of the adult SVZ [8].
We need to understand the molecular determinants regulating ER DNA binding and activity to elucidate the mechanisms underlying this resistance.
Similar(57)
The molecular determinants regulated by p53 that are required for the acquisition and the maintenance of stemness traits in normal and tumour cells remain largely unknown.
The fact that both Yan concentration and noise were easily measured using our approach indicates that it provides a powerful method for studying how other molecular determinants regulate cell states.
Matrix Gla protein (MGP) is a molecular determinant regulating vascular calcification of the extracellular matrix.
Despite the progress made in characterizing hMSC differentiation, the molecular determinants that regulate osteogenesis are not completely understood.
Little is known, however, about the molecular determinants that regulate homing of breast cancer cells to bone.
Much remains to be understood of the molecular determinants that regulate cell survival and death in intestinal epithelial cells (IECs), including their roles in the development of gastrointestinal disorders.
Knowledge of molecular determinants that regulate stem cell fate and understanding their functions are key challenges for future therapy based on stem cells in which their plasticity has to be properly controlled.
Although the strong influence of environmental factors and genotypic × environment interactions could mask the effects of minor QTLs, the genetic determinants regulating sugar accumulation could be identified, allowing for the identification of molecular markers to be used in marker-assisted selection (MAS) or breeding (MAB).
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