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Matrix Gla protein (MGP) is a molecular determinant regulating vascular calcification of the extracellular matrix.
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Molecular determinants regulating the activation of class B G-protein-coupled receptors (GPCRs) by native peptide agonists are largely unknown.
Moreover, several arguments advise caution before grafting NSCs in patients that include, a) evidence that glioblastoma may arise de novo from the oncogenic transformation of NSCs [1], [4], b) common molecular determinants regulating neurogenesis and tumorigenesis [5] [7], and c) generation of glioma-like lesions following growth factor stimulation of the adult SVZ [8].
We need to understand the molecular determinants regulating ER DNA binding and activity to elucidate the mechanisms underlying this resistance.
The fact that both Yan concentration and noise were easily measured using our approach indicates that it provides a powerful method for studying how other molecular determinants regulate cell states.
DNA methylation is a reversible epigenetic determinant regulating cellular differentiation.
Despite the progress made in characterizing hMSC differentiation, the molecular determinants that regulate osteogenesis are not completely understood.
Little is known, however, about the molecular determinants that regulate homing of breast cancer cells to bone.
Much remains to be understood of the molecular determinants that regulate cell survival and death in intestinal epithelial cells (IECs), including their roles in the development of gastrointestinal disorders.
Knowledge of molecular determinants that regulate stem cell fate and understanding their functions are key challenges for future therapy based on stem cells in which their plasticity has to be properly controlled.
Furthermore, an exploration of the molecular determinants involved in regulating calcineurin activity revealed that significant differences in the subcellular distribution of free Ca2+/CaM are responsible for generating these discrete activity patterns.
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