Starting from the Aviram Ratner molecular diode design, we follow the progress of molecular electronics from simple discrete molecular devices towards quantum computing at the molecular scale.
We report the design and synthesis of an insulin receptor kinase family-targeted inhibitor template using the inhibitor conformation observed in an IGF1R/inhibitor co-crystal complex by application of a novel molecular design approach that we have recently published.
The molecular design strategy that we have employed is illustrated in Figure 2. Thus, an oligonucleotide that can form a duplex with an siRNA is covalently attached to the handle of an activated molecular umbrella via thiolate disulfide exchange.
In this paper, by introducing [1,2,5]thiadiazolo[3,4-c]pyridine (PT) as an auxiliary acceptor into the molecular design of organic sensitizers, we have synthesized four new dyes (PT1 PT4) for dye-sensitized solar cells (DSSCs) with triphenylamine or N,N-diphenylthiophen-2-amine as the donor units and thiophene or benzene as the π-bridges, respectively.
We demonstrate molecular design strategies for engineering the deformation rate sensitivity and fracture resistance of organic-inorganic hybrid films in moist environment.
Here, we performed molecular design of halogen bonding orthogonal to hydrogen bonding at the complex interface of MDM2 protein with its cognate peptide ligand to improve the peptide binding affinity and specificity.
Using the extracellular matrix protein fibronectin as an example, we discuss molecular design principles that might control the exposure of a protein's recognition sites, and/or their relative distances, in a force-dependent manner.
We also demonstrate that both catechol and methyl phosphonic acid are promising binding groups for NiO sensitizers to replace classical carboxylic acids in NiO sensitizers and finally we report molecular design rules to elaborate a new generation of better performing ruthenium polypyridine sensitizers.
To test this hypothesis and thus provide the molecular design guidelines for optimal sensitivity, we evaluated the effect of modulating the hydrophilic lipophilic balance of the dendron upon the response time in signal generation.
